There are quite a few opportunities to fly solo in EVE. Usually, solo gameplay will not be as rewarding as group gameplay in EVE, be it in ISK/hour or fun/hour. In addition, many of these activities can be much more enjoyable for those who choose to play multiple accounts simultaneously (multibox), e.g. in mining or ratting.
The majority of players will find mining very boring. It’s not for everyone, but some people find it enjoyable. Many players enjoy relaxing in asteroid belts in high security space, mining rocks. Mining solo isn’t usually very profitable. You might make a few million ISK an hour, but without additional support, many superior alternatives exist. However, it can be very lucrative if multiboxed. One could make hundreds of millions of ISK every day running a few accounts with some Hulks and an Orca in null security or wormhole space. It takes an initial time and capital investment, as well as iron willpower, but it can be done entirely by one person.
Missions, particularly level 4 missions, are another way to make decent money with almost no risk in high security space. Running missions for a corporation grants you ISK, loot, salvage, and loyalty points. Simply pick a corporation and start doing missions for them until level 4 agents are unlocked. The easiest way to make ISK is to train into a solid ship (Tengus tend to work best) and find a level 4 security agent. After accepting a mission, search Google to find details on spawns and objectives. Loyalty points are used to purchase faction equipment, and serve as a bonus reward for running missions. Be sure to use a loyalty point calculator to choose which items to spend your LP on before cashing out.
I made a video guide about null security space ratting. Though it is riskier than the above activities, it can be more lucrative, certainly for someone with only one account. There are two types of ratting: ratting in asteroid belts and in anomalies. Ratting in asteroid belts produces less ISK per hour than anomalies, but it gives you the chance to kill a rare officer spawn, which can give you loot in the billions. I have only ever killed one officer, but he dropped around 2 billion ISK in loot. Belt ratting consists of warping from belt to belt killing rats and hoping for an officer spawn.
Ratting in anomalies is a little different. Open up your probe scanner, go to the system scanner tab, and use your on-board scanner to scan the system for anomalies. They range in difficulty and the more difficult they are, the more valuable they tend to be. Anomalies provide steady ISK per hour in the form of bounties, but they can provide additional revenue two other ways. The first is through faction spawns, which are rare spawns similar to officers but not as valuable. They drop loot such as Dread Guristas modules which can sell for hundreds of millions of ISK. The second way is through escalations, which can turn an ordinary anomaly into a bookmark for a DED plex, such as a 10/10 Maze escalation which can be worth billions.
Daytripping in a wormhole involves jumping into a wormhole alone, running some sites, making your way out without ever setting up a home. It can be done entirely solo provided you have the capabilities of being self-sufficient (scanning, looting, salvaging, and killing on your own). Rather than going in-depth on my own, I’ll point you to a rather well written guide written by redditor paxNoctis.
Solo PVP isn’t as much a way to make ISK as it is a way to have fun. It’s pretty easy but far too complex for the scope of this post. The basics are to fit a nice solo-capable ship, find some targets, and kill or be killed. A lot of fits are available through Google, or through the rookie help channel. There is no objective best when it comes to fitting a ship, so don’t be afraid to experiment. Targets can be found everywhere, but for some quick fights try heading into Faction Warfare space in low security space.
If anyone has any more suggestions for additions to the list, feel free to drop a comment on this post and I will update the list as your suggestions come in. Fly safe (or dangerous) everyone! o7